Bioenergetics homeostasis is important for cells to sustain normal functions and defend against injury. Genetics controls on bioenergetics homeostasis, including lipid and glucose metabolism remain poorly understood in chronic obstructive pulmonary diseases (COPD). Our recent data have suggested that regulation on cellular or even whole body metabolism might be a shared mechanism among COPD GWAS genes that may potentially determine the cellular injury response and/or repair capacity in lung epithelial cells in response to chronic cigarette smoke exposure.