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Gong L, Bates S, Li J, Qiao D, Glass K, Wei W, Hsu VW, Zhou X, Silverman EK. Connecting COPD GWAS genes: FAM13A controls TGFβ2 secretion by modulating AP-3 transport. Am J Respir Cell Mol Biol. 2021 Jun 24. doi: 10.1165/rcmb.2021-0016OC. Epub ahead of print. PMID: 34166600.

Li Y, Zhang L, Polverino F, Guo F, Hao Y, Lao T, Xu S, Li L, Pham B, Owen CA, Zhou X. Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells. Sci Rep. 2021 Apr 27;11(1):9074. doi: 10.1038/s41598-021-88434-x. PMID: 33907231; PMCID: PMC8079715.

Benway CJ, Liu J, Guo F, Du F, Randell SH, Cho MH, Silverman EK, Zhou X; International COPD Genetics Consortium. Chromatin Landscapes of Human Lung Cells Predict Potentially Functional Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Variants. Am J Respir Cell Mol Biol. 2021 Jul;65(1):92-102. doi: 10.1165/rcmb.2020-0475OC. PMID: 33788674.

Lin X, Li Y, Gong L, Yun JH, Xu S, Tesfaigzi Y, Qiao D, Zhou X. Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the stemness of alveolar epithelial progenitors. EBioMedicine. 2021 Jul 2;69:103463. doi: 10.1016/j.ebiom.2021.103463. Epub ahead of print. PMID: 34224973.

Lin X, Liou YH, Li Y, Gong L, Li Y, Hao Y, Pham B, Xu S, Jiang Z, Li L, Peng Y, Qiao D, Lin H, Liu P, Wei W, Zhang G, Lee CH, Zhou X. FAM13A Represses AMPK Activity and Regulates Hepatic Glucose and Lipid Metabolism. iScience. 2020 Mar 27;23(3):100928. PMID: 32151973

Hao Y, Bates S, Mou H, et al. GWAS Functional Variant rs2076295 Regulates Desmoplakin (DSP) Expression in Airway Epithelial Cells[published online ahead of print, 2020 Jun 18]. Am J Respir Crit Care Med. 2020;10.1164/rccm.201910-1958OC. doi:10.1164/rccm.201910-1958OC. PMID: 32551799

Maiorino E, Baek SH, Guo F, Zhou X, Kothari PH, Silverman EK, Barabási AL, Weiss ST, Raby BA, Sharma A. Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome.Nat Commun. 2020 Feb 10;11(1):811.

Kelly RS, Chawes BL, Guo F, Zhang L, Blighe K, Litonjua AA, Raby BA, Levy BD, Rago D, Stokholm J, Bønnelykke K, Bisgaard H, Zhou X, Lasky-Su JA, Weiss ST. The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D. Eur Respir J. 2019 Oct 24;54(4).

Saferali A, Yun JH, Parker MM, Sakornsakolpat P, Chase RP, Lamb A, Hobbs BD, Boezen MH, Dai X, de Jong K, Beaty TH, Wei W, Zhou X, Silverman EK, Cho MH, Castaldi PJ, Hersh CP; COPDGene Investigators; International COPD Genetics Consortium Investigators. Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene. PLoS Genet. 2019 Jul 3;15(7):e1008229.

Parker MM, Hao Y, Guo F, Pham B, Chase R, Platig J, Cho MH, Hersh CP, Thannickal VJ, Crapo J, Washko G, Randell SH, Silverman EK, San José Estépar R, Zhou X#, Castaldi PJ#. Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts. Elife. 2019 Jul 25;8. (#, Co-corresponding author)

Boueiz A, Pham B, Chase R, Lamb A, Lee S, Naing ZZC, Cho MH, Parker MM, Sakornsakolpat P, Hersh CP, Crapo JD, Stergachis AB, Tal-Singer R, DeMeo DL, Silverman EK, Zhou X, Castaldi PJ; COPDGene investigators. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2019, April; 60(4): 388-398.43.

Sakornsakolpat P*, Prokopenko D*, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC, Li X, Morrow JD, Obeidat M, Wyss AB, Bakke P, Barr RG, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJ, Lomas DA, London SJ, Meyers DA, O’Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim JJ, Zhou X, Bossé Y, Manichaikul A, Lahousse L, Silverman EK, Boezen HM, Wain LV, Tobin MD, Hobbs BD#, Cho MH#, SpiroMeta Consortium; International COPD Genetics Consortium. Expanded genetic landscape of chronic obstructive pulmonary disease reveals heterogeneous cell type and phenotype associations. Nature Genetics. 2019. Mar;51(3):494-505. (*, Co-first author; #, Co-corresponding author)

Zhang J, Chen M, Zhu Y, Dai X, Dang F, Ren J, Ren S, Shulga YV, Beca F, Gan W, Wu F, Lin YM, Zhou X, DeCaprio JA, Beck AH, Lu KP, Huang J, Zhao C, Sun Y, Gao X, Pandolfi PP, Wei W. SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. Dev Cell. 2019 Feb 11;48(3):329-344.e5.

Castaldi P*, Guo F*, Qiao D*, Du F1, Naing  Z, Li Y1, Pham B, Mikkelsen T, Cho MH, Silverman EK, Zhou X. Identification of Functional Variants in the FAM13A Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Locus by Massively Parallel Reporter Assays.Am J Respir Crit Care Med. 2019 Jan 1;199(1):52-61. (*, Co-first author)

Sharma A, Kitsak M, Cho MH, Ameli A, Zhou X, Jiang Z, Crapo JD, Beaty TH, Menche J, Bakke PS, Santolini M, Silverman EK. Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module. Sci Rep. 2018 Sep 27;8(1):14439.

Glass K, Thibault D, Guo F, Mitchel JA, Pham B, Qiu W, Li Y, Jiang Z, Castaldi P, Silverman EK, Raby B, Park JA, Yuan GC, Zhou X. Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke. Sci Rep. 2018 Aug 24;8(1):12750.

Qiu W*, Guo F*, Glass K, Yuan GC, Quakenbush J, Zhou X, Tantisira K. Differential Connectivity of Gene Regulatory Networks Distinguishes Corticosteroid Response in Asthma.J of Allergy and Clinical Immunology. 2018 Apr;141(4):1250-8. (*Co-first author)

Musunuru K, Bernstein D, Cole FS, Khokha MK, Lee FS, Lin S, McDonald TV, Moskowitz IP, Quertermous T, Sankaran VG, Schwartz DA, Silverman EK, Zhou X, Hasan AAK, Luo XJ. Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research. Circ Genom Precis Med. 2018 Apr;11(4):e002178.

Morrow JD, Cho MH, Platig J, Zhou X, DeMeo DL, Qiu W, Celli B, Marchetti N, Criner GJ, Bueno R, Washko GR, Glass K, Quackenbush J, Silverman EK, Hersh CP. Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease.Hum Genomics. 2018 Jan 15;12(1):1.

Li Y, Cho MH, Zhou X. What do polymorphisms tell us about the mechanisms of COPD?Clinical Science, 2017, Dec 4;131(24):2847-63.

Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP. Transcriptomic Analysis of Lung Tissue from Cigarette Smoke Induced Emphysema Murine Models and Human COPD Show Shared and Distinct Pathways. Am J Respir Cell Mol Biol. 2017 Jul;57(1):47-58.

Li J, Zou L, Zhou Y, Li L, Zhu Y, Yang Y, Gong Y, Lou J, Ke J, Zhang Y, Tian J, Zou D, Peng X, Chang J, Gong J, Zhong R, Zhou X, Miao X. A low-frequency variant in SMAD7 modulates TGF-βsignaling and confers risk for colorectal cancer in Chinese population.Mol Carcinog. 2017 Jul;56(7):1798-1807.

Jiang Z, Knudsen N, Wang G, Qiu W, Naing Z, Bai Y, Ai X, Lee C, Zhou X; Genetic control of fatty acid β-oxidation in chronic obstructive pulmonary disease.Am J Respir Cell Mol Biol. 2017 Jun;56(6):738-48.

Wan ES, Li Y, Lao, T, Qiu W, Jiang Z, Mancini JD, Owen CA, Clish C, DeMeo DL, Silverman EK, Zhou X. Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease.Scientific Report, 2017 May 31;7(1):2504.

Morrow J.D, Zhou X, Lao T, Jiang Z, DeMeo D, Cho MH, Qiu W, Cloonan S, Pinto-Plata V, Celli B, Marchetti N, Criner G et al. Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue.Scientific Report. 2017 Mar 13;7:44232.

McGeachie MJ*, Yates KP*, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST; CAMP Research Group. Genetics and Genomics of Longitudinal Lung Function Patterns in Asthmatics.Am J Respir Crit Care Med. 2016, Dec 15;194(12):1465-74.

Girodet PO, Nguyen D, Mancini JD, Hundal M, Zhou X, Israel E, Cernadas M. Alternative Macrophage Activation is Increased in Asthma.Am J Respir Cell Mol Biol. 2016, Oct;55(4):467-75.

Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X. Hhip haploinsufficiency sensitizes mice to age-related emphysema.Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4681-7.

Jiang Z, Polverino F, Lao T, Qiu W, Gupta K, Mancini J.D, Cho MH, Castaldi PJ, Guo F, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AMK, Perrella MA, Owen CA., Silverman EK and Zhou XA. Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin. Am J Respir Crit Care Med. 2016, Jul 15;194(2):185-97.

Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agusti A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MH; NETT Genetics, ECLIPSE, COPDGene and International COPD Genetics Network Investigators. Exome Array Analysis Identifies A Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease.Am J Respir Crit Care Med. 2016 Jul 1;194(1):48-57.

Sharma A, Menche J, Huang C, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA Jr, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Barabási AL. A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes. Hum Mol Genet. 2015 Jun 1;24(11):3005-20.

McGeachie MJ*, Yates KP*, Zhou X, Guo F, Sternberg AL, Van Natta M, Wise RA, Szefler S, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman G, Postma D, Raby B, Houston I, Lu Q, Fuhlbrigge A, Tantisira K, Silverman EK, Tonascia J, Weiss ST, Strunk RC. Patterns of Lung Function Growth and Decline in Persistent Childhood Asthma.N Engl J Med. 2016 May 12;374(19):1842-52.

Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15;24(4):1200-10.

LaoT, Glass K, QiuW, GuptaK, MorrowJ, ManciniJD, VuongL, PerrellaMA, HershCP, OwenCA, QuackenbushJ, YuanG, Silverman EK, and ZhouX*. Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med. 2015 Feb 14;7(1):12.

Sharma S*, Zhou X*, Thibault DT, Himes BE, Liu A, Szefler SJ, Strunk R, Castro M, Hansel N, DietteGB, Vonakis BM, Adkinson NF, Avila L, Soto-Quiros M, Barraza-Villareal A, Lemanske RF, Solway J, Krishnan J, White SR, Cheadle C, Berger AE, Fan J, Boorgula MP, Nicolae D, Gilliland F, Barnes K,. London SJ, Martinez F, OberC, Celedón J, Carey VJ, Weiss ST, Raby RA. A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes.J Allergy Clin Immunol. 2014 Nov;134(5):1153-62.

Cho M, McDonald M., Zhou X, Mattheisen M, Castaldi P, Hersh C, DeMeo D, Sylvia J, Ziniti J, Laird N, Lange C, Litonjua A, Sparrow D, Casaburi R, Barr R, Regan E, MD, Make B, Hokanson J, Lutz S, Dudenkov T, Farzadegan H, Hetmanski J, Tal-Singer R, Lomas D, Bakke P, Gulsvik A, Crapo J, Silverman EK, Beaty TH. A Genome-Wide Association Identifies Risk Loci for Severe Chronic Obstructive Pulmonary Disease.Lancet Respiratory Medicine, 2014, Mar; 2(3):214-25.

Li CG, Zhou X, Sun Y, Zhang E, Mancini JD, Parkhitko A, Morrison TA, Silverman EK, Henske EP, Yu J. Faslodex inhibits estradiol-induced ECM dynamics and lung metastasis in a model of LAM.Am J Respir Cell Mol Biol. 2013 Jul;49(1):135-42.

Zhou X#, Qiu W, Sathirapongsasuti JF, Cho MH, Mancini JD, Lao T, Thibault DM, Litonjua G, Bakke PS, Gulsvik A, Lomas DA, Beaty TH, Hersh CP, Anderson C, Geigenmuller U, Raby BA, Rennard SI, Perrella MA, Choi AMK, Quackenbush J, Silverman EK#. Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells.Genomics. 2013 May;101(5):263-72. (#corresponding author).

Zhou X#, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski,P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AMK, Silverman EK#. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.Human Molecular Genetics, 2012, Mar 15;21(6):1325-35. (#corresponding author)

Lange N.E, Zhou X, Lasky-Su J, Himes B.E., Lazarus R, Soto-Quiros M, Avila L, Celedon J C, Hawrylowicz C M, Raby BA and Litonjua A. Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes.BMC Med Genet.2011 Feb 15;12:26.

Zhou X#, Münger K. Clld7, A Candidate Tumor Suppressor on Chromosome 13q14, Regulates Pathways of DNA Damage/Repair and Apoptosis.Cancer Res. 2010 Nov 15;70(22):9434-43. (#corresponding author)

Yang S, He S, Zhou X, Liu M, Zhu H, Wang Y, Zhang W, Yan S, Quan L, Bai J, Xu N. Suppression of Aurora-A Oncogenic Potential by c-Myc Down regulation. Exp Mol Med. 2010 Nov 30;42(11):759-67.

Zhou X, Münger K. Expression of the Human Papillomavirus type 16 E7 oncoprotein induces an autophagy-related process and sensitizes normal human keratinocytes to cell death in response to growth factor deprivation.Virology. 2009 Mar 1;385(1):192-7.

Zhou X, Spangle JM, Münger K. Expression of a viral oncoprotein in normal human epithelial cells triggers an autophagy-related process: Is autophagy an “Achilles’ heel” of human cancers?Autophagy. 2009 May;5(4):578-9.

Wang Y, Liu S, Zhu H, Zhang W, Zhang G, Zhou X, Zhou C, Quan L, Bai J, Xue L, Lu N, Xu N. FRAT1 overexpression leads to aberrant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma.Int J Cancer. 2008 Aug 1;123(3):561-8.

Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Harper JW, Munger K. The Human Papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor.J Virol. 2007 Sep;81(18):9737-47.

Yang SB*, Zhou X*, Zhu HX, Quan LP, Bai JF, He J, Gao YN, Cheng SJ, Xu NZ. Amplification and Overexpression of Aurora-A in Esophageal Squamous Cell Carcinoma.Oncol Rep. 2007 May;17(5):1083-8. (*Co-first author).

Wang Y, Hewitt SM, Liu S, Zhou X, Zhu H, Zhou C, Zhang G, Quan L, Bai J, Xu N. Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours.Br J Cancer. 2006 Mar 13;94(5):686-91.

Zhang G*, Zhou X*, Xue L, Quan L, Wang Y, Zhou C, Lu N, Wang Q, Zhu H, Xu N. (*Co-first author). Accumulation of cytoplasmic beta-catenin correlates with reduced expression of E-cadherin, but not with phosphorylated Akt in esophageal squamous cell carcinoma: an immunohistochemical study. Pathology International.Pathol Int. 2005 Jun;55(6):310-7.

Wang Y*, Zhou X*, Zhu H, Liu S, Zhou C, Zhang G, Xue L, Lu N, Quan L, Bai J, Zhan Q, Xu N. (*Co-first author). Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC): promoting cellular growth by the activating beta-catenin/TCF pathway.Oncogene. 2005 Oct 6;24(44):6637-45.

Zhou C, Liu S, Zhou X, Xue L, Quan L, Lu N, Zhang G, Bai J, Wang Y, Liu Z, Zhan Q, Zhu H, Xu N. Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin/TCF pathway in human esophageal squamous cell carcinoma.Int J Cancer. 2005 Mar 1;113(6):891-8.

Wang YH, Liu S, Zhang G, Zhou CQ, Zhu HX, Zhou X, Quan LP, Bai JF, Xu NZ. Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo. Breast Cancer Res. 2005;7(2):R220-8.

Zhou X, Guo M, Quan LP, Zhang W, Lu ZM, Wang QH, Ke Y, Xu NZ. Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium.World J Gastroenterol. 2003 Jun;9(6):1170-3.

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